First established at Wake Forest University, The Entanglements Network grew from the 2019 Reynolda Conference, Entanglements: A Conference on the Intersections of Poetry, Science, and the Arts, convened by Amy Catanzano with an Andrew W. Mellon Foundation-funded award from the Wake Forest Humanities Institute and the Reynolda House Museum of American Art.

The conference brought together leading poets, scientists, artists, and scholars from the United States, Canada, and Spain for three days of innovative programming and performance.

Featured presenters at Wake Forest Entanglements were poet Will Alexander, ecologist and poet Madhur Anand, poet Rae Armantrout, poet Amy Catanzano, poet Andrew Joron, artist Eduardo Kac, particle physicist Mark C. Kruse, literary scholar Ming-Qian Ma, poet Ed Roberson, scientist and writer Gustavo A. Schwartz, and poet Anne Waldman. Special guests were poet Lee Ann Brown, transmedia artist Elæ Moss, poet Adam Dickinson, astrophysicist Satya Gontcho A Gontcho, poet Stephanie Strickland, and poet Edwin Torres. Conference collaborators were poet Maddie Baxter and poet EJ Baird. Wake Forest faculty and staff presenters were transmedia artist Lynn Book, artist and curator Paul Bright, art scholar John Curley, neurobiologist Wayne Silver, and literary scholar Elizabeth A. Way.